Recombination of influenza a strains with fowl plague virus can change pneumotropism for mice to a generalized infection with involvement of the central nervous system
Identifieur interne : 002801 ( Main/Exploration ); précédent : 002800; suivant : 002802Recombination of influenza a strains with fowl plague virus can change pneumotropism for mice to a generalized infection with involvement of the central nervous system
Auteurs : Angelika Vallbracht [Allemagne] ; C. Scholtissekt [Allemagne] ; B. Flehmig [Allemagne] ; H.-J. Gerth [Allemagne]Source :
- Virology [ 0042-6822 ] ; 1980.
English descriptors
- Teeft :
- Certain polymerase proteins, Cultured mouse embryo fibroblasts, Embryo, Fibroblast, Flehmig, Fowl, Fowl plague virus, Generalized infection, Havl, Havl hemagglutinin, Hemagglutinin, Hemagglutinin havl, Host range, Infection, Infectious virus, Influenza, Influenza viruses, Inoculation, Intranasal, Mouse, Mouse embryo fibroblasts, Mouse virulence, Neurotropic recombinants, Neurovirulence, Neurovirulent, Neurovirulent recombinants, Neurovirulent strains, Newborn mouse, Parent strains, Parental genes, Pathogenicity, Pneumovirulent, Pneumovirulent strains, Polymerase, Ptra, Recombinant, Recombination, Recombination system, Replication, Respiratory infection, Rott, Scholtissek, Suckling, Suckling mice, Transport gene, Trypsin, Trypsin treatment, Vallbracht, Virology, Virus, Virus replication.
Abstract
Abstract: Recombination between fowl plague virus FPV/Rostock (Hav1N1), an influenza A strain which produces a generalized fatal infection with involvement of the central nervous system in chickens, and mouse lung-adapted human strains England/1/61 (H2N2) or PR/8/34 (H0N1 results in recombinants which produce a generalized infection in suckling mice with involvement of the central nervous system. A combination of the hemagglutinin and M protein from FPV/Rostock (Hav1N1) with certain polymerase proteins from the mouse lung-adapted strains produces generalized infections in mice. Infectious virus was present in lung, brain, and blood even after intranasal infection. A correlation between the ability to induce a generalized infection of suckling mice in vivo and the replication in mouse embryo fibroblasts in vitro could be demonstrated.
Url:
DOI: 10.1016/0042-6822(80)90312-8
Affiliations:
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A combination of the hemagglutinin and M protein from FPV/Rostock (Hav1N1) with certain polymerase proteins from the mouse lung-adapted strains produces generalized infections in mice. Infectious virus was present in lung, brain, and blood even after intranasal infection. A correlation between the ability to induce a generalized infection of suckling mice in vivo and the replication in mouse embryo fibroblasts in vitro could be demonstrated.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Vallbracht, Angelika" sort="Vallbracht, Angelika" uniqKey="Vallbracht A" first="Angelika" last="Vallbracht">Angelika Vallbracht</name></region><name sortKey="Flehmig, B" sort="Flehmig, B" uniqKey="Flehmig B" first="B." last="Flehmig">B. Flehmig</name><name sortKey="Gerth, H J" sort="Gerth, H J" uniqKey="Gerth H" first="H.-J." last="Gerth">H.-J. Gerth</name><name sortKey="Scholtissekt, C" sort="Scholtissekt, C" uniqKey="Scholtissekt C" first="C." last="Scholtissekt">C. Scholtissekt</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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